Prader willi facial characteristics

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A key feature of Prader-Willi syndrome is a constant sense of hunger that usually begins at about 2 years of age. People with Prader-Willi syndrome want to eat constantly because they never feel full hyperphagiaand they usually have trouble controlling their weight. Many complications of Prader-Willi syndrome are due to obesity.

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To complement the Annual Clinical Focus on medical genomics, AFP is publishing a series of short reviews on genetic syndromes. This series was designed to increase awareness of these diseases so that family physicians can recognize and diagnose children with these disorders and understand the type of care they might require in the future. This review discusses Prader-Willi syndrome.

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Prader—Willi syndrome PWS is a genetic disorder due to loss of function of specific genes. Prader—Willi syndrome has no cure. PWS affects between one in 10, and one in 30, people.

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Back to Prader-Willi syndrome. Prader-Willi syndrome can cause a wide range of symptoms, and affect your child's physical, psychological and behavioural development. Floppiness caused by weak muscles is usually noticed shortly after birth.

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Objectives: To describe six patients younger than 3 years of age who were diagnosed with Prader-Willi syndrome due to the presence of hypotonia, poor sucking, slight facial anomalies and minor anomalies of hands and feet. Prader-Willi syndrome is a neurobehavioral disorder characterized by two distinct phases; in the first phase, the neonate presents variable degrees of hypotonia, feeding problems with none or poor sucking, hypogonadism, characteristic facial features with almond-shaped eyes, narrow bifrontal diameter and corners of the mouth turned downwards. Neuropsychomotor development is delayed.

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PWS is characterised by hyptonia and feeding problems in infancy, hypogonadism, characteristic facial features, short stature, developmental delay, obesity and an obsession with food and eating. It was further updated in What is Prader-Willi Syndrome?

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Prader-Willi syndrome PWS is a genetic multisystem disorder characterized during infancy by lethargy, diminished muscle tone hypotoniaa week suck and feeding difficulties with poor weight gain and growth and other hormone deficiency. In childhood, features of this disorder include short stature, small genitals and an excessive appetite. Affected individuals do not feel satisfied after completing a meal satiety. Without intervention, overeating can lead to onset of life-threatening obesity.

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Inheritance It is sporadic and familial cases are rare. The incidence is Etiology: PWS is genetically heterogeneous.

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